Orofacial neuropathic pain induced by oxaliplatin
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چکیده
منابع مشابه
Orofacial neuropathic pain induced by oxaliplatin
Abstract Neuropathic pain induced by chemotherapy drugs such as oxaliplatin is a dose-limiting side effect in cancer treatment. The mechanisms underlying chemotherapy-induced neuropathic pain are not fully understood. KCNQ2 channels are low-threshold voltage-gated K+ channels that play a role in controlling neuronal excitability. Downregulation of KCNQ2 channels has been proposed to be an under...
متن کاملNeuropathic orofacial pain.
Neuropathic orofacial pain (NOP) is a challenging diagnostic problem. In some cases, symptomatology may be similar to that seen with dental pathology, resulting in unwarranted dental treatment. Rarely, NOP can herald serious disease or central tumors, and early diagnosis can be life-saving. The following review outlines the classification, clinical presentation, pathophysiology, and treatment o...
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One of the most challenging clinical issues the dentist confronts is the patient with persistent orofacial pain without obvious proximate physical cause. Patients with persistent pain often seek consultation from many clinicians and undergo multiple unnecessary procedures before receiving a correct diagnosis and appropriate treatment. Clinicians unfamiliar with neuropathic pain may become frust...
متن کاملA TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain
Neuropathic pain (NeP) is generally considered an intractable problem, which becomes compelling in clinical practice when caused by highly effective chemotherapeutics, such as in the treatment of cancer with oxaliplatin (OXA) and related drugs. In the present work we describe a structurally new compound, ADM_09, which proved to effectively revert OXA-induced NeP in vivo in rats without elicitin...
متن کاملMexiletine reverses oxaliplatin-induced neuropathic pain in rats.
Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na(+)-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effect of mexiletine on oxaliplatin-induced neuropathic pain in rats. Mexiletine (100, but not 10 an...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2017
ISSN: 1744-8069,1744-8069
DOI: 10.1177/1744806917724715